IL-12 ameliorates diabetic retinal neurodegeneration by activating microglial phagocytosis via the TREM2/DAP12 pathway
Wanyi Fang, Shanshan Liu, Yifei Wu, Ting Chen, Xiaohe Lu, Hui Chen · 2025
Read IL-12 ameliorates diabetic retinal neurodegeneration by activating microglial phagocytosis via the TREM2/DAP12 pathway by Wanyi Fang, Shanshan Liu, Yifei Wu, Ting Chen, Xiaohe Lu, Hui Chen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12664847.txt.
Description
Wanyi Fang and co-authors find that an immune signal can protect the diabetic retina by waking its resident cleanup cells. Diabetes slowly damages retinal nerves before vessels fail, and early protection is scarce. In diabetic mice, injections of interleukin-12 into the eye partly spared the nerve fiber and ganglion cell layers from thinning.
Gene profiling pointed at microglia, the retina's immune cells, and their eating activity. The signal switched on a pathway through STAT4 that raised two partner proteins, TREM2 and DAP12, boosting the cells' growth and appetite even in high sugar. Lab tests confirmed the chain. The authors propose this route as an early treatment target before vision is lost.
Catalog record
| CREATOR | Wanyi Fang, Shanshan Liu, Yifei Wu, Ting Chen, Xiaohe Lu, Hui Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |