Developmental timing of auditory deprivation influences spatial memory and hippocampal plasticity in rats
Marjan Mirsalehi, Alimohamad Asghari, Masoud Nasiri Nasab Rafsanjani, Akram Pourbakht, Maryam Balali, Sayedali Ahmadi, Zeinab Akbarnejad · 2025
Read Developmental timing of auditory deprivation influences spatial memory and hippocampal plasticity in rats by Marjan Mirsalehi, Alimohamad Asghari, Masoud Nasiri Nasab Rafsanjani, Akram Pourbakht, Maryam Balali, Sayedali Ahmadi, Zeinab Akbarnejad (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12663570.txt.
Description
Marjan Mirsalehi and co-authors report a rat study, published in 2025, on how the age at which hearing is lost shapes memory later. The hearing loss of early childhood is often treated as an ear problem, yet the hippocampus, the brain's memory hub, depends on sound driven input as it develops. Rats lost hearing at four different ages, from two weeks old to young adulthood, and were tested at four months.
Animals deafened as newborns kept normal spatial memory, while those deafened at four weeks or as adults fared worst. New neuron growth and synaptic plasticity markers fell in step with the memory losses. The authors conclude that later hearing loss harms the hippocampus more, a timing lesson for care after childhood deafness.
Catalog record
| CREATOR | Marjan Mirsalehi, Alimohamad Asghari, Masoud Nasiri Nasab Rafsanjani, Akram Pourbakht, Maryam Balali, Sayedali Ahmadi, Zeinab Akbarnejad |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |