SKP2 protein as a prognostic biomarker for glioma and promotes tumor progression by regulating the cell cycle
Lei Guan, Haima Li, Yezu Liu, Jia Ouyang, Changxiang Yan, Feng Liu · 2025
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Description
Lei Guan and co-authors examine the cell-cycle protein SKP2 as a warning sign and driver in glioma, in a 2025 study. The team compared SKP2 levels with patient features and survival in their datasets, mined the genes that differ between high and low SKP2 tumors, and built a prediction model. Lab tests then silenced the gene in two glioma cell lines.
High SKP2 tracked with worse tumor features and shorter survival, and the differing genes clustered around cell division. Silencing SKP2 froze the cells in the G1 phase, stalling the cycle. The authors propose SKP2 as both a prognostic marker and a possible drug target, while asking for prospective validation before clinical use.
Catalog record
| CREATOR | Lei Guan, Haima Li, Yezu Liu, Jia Ouyang, Changxiang Yan, Feng Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |