RING1B-BMI1 catalyzed dynamic H2AK119ub1 modification in response to sonic hedgehog signalling during pancreatic differentiation of human embryonic stem cells
Niloufer P. Dumasia, Prasad S. Pethe · 2025
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Description
Niloufer Dumasia and Prasad Pethe study how a signaling pathway guides stem cells toward becoming pancreas cells. Human embryonic stem cells can be coaxed into the pancreatic line in a dish, offering a model of early development. Two proteins, RING1B and BMI1, tag genes to keep them switched off during this process.
A signal called sonic hedgehog must be quieted for pancreas formation to proceed. The team asked whether that signal also directs the two proteins onto pancreas genes. Using a method that fishes out protein-bound DNA, they compared cells given the signal with cells given a blocker. The signal changed both the activity of key pancreas genes and how much the two proteins sat on their control regions. Occupancy tracked two genes closely, yet the master pancreas switch stayed unchanged, showing the pathway steers gene silencing in this step.
Catalog record
| CREATOR | Niloufer P. Dumasia, Prasad S. Pethe |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |