Reconstruction of the transcriptional regulatory networks in the kidney of desert-adapted species
Fernando Alvira-Iraizoz, Benjamin T Gillard, Audrys G Pauža, Panjiao Lin, Alex Paterson, Pamela A Burger, Mahmoud Hag Ali, Nabil Amor, Abdulaziz N Alagaili, Abdu Adem, David Murphy, Michael P Greenwood · 2025
Read Reconstruction of the transcriptional regulatory networks in the kidney of desert-adapted species by Fernando Alvira-Iraizoz, Benjamin T Gillard, Audrys G Pauža, Panjiao Lin, Alex Paterson, Pamela A Burger, Mahmoud Hag Ali, Nabil Amor, Abdulaziz N Alagaili, Abdu Adem, David Murphy, Michael P Greenwood (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12663168.txt.
Description
Fernando Alvira-Iraizoz and a large team rebuild the gene control networks of desert animal kidneys in a 2025 study. Camels and jerboas endure long spells without water, and their kidneys are central to that feat. The team had earlier profiled kidney gene activity in these animals under water stress, finding a role for cholesterol handling in camels.
Now they mine those data to wire up the networks: which switch genes control which targets in camel, jerboa, and olive mouse kidneys, under wet and dry regimes. In all, they found 283 switch genes that changed with conditions and 209 networks. Two fat-handling switches, SREBF1 and SREBF2, stand out across species. The maps point to shared tricks that dry-country mammals use to save water.
Catalog record
| CREATOR | Fernando Alvira-Iraizoz, Benjamin T Gillard, Audrys G Pauža, Panjiao Lin, Alex Paterson, Pamela A Burger, Mahmoud Hag Ali, Nabil Amor, Abdulaziz N Alagaili, Abdu Adem, David Murphy, Michael P Greenwood |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |