A phase 1/2 study of DS-1594 menin inhibitor in relapsed/refractory acute leukemias
Jayastu Senapati, Marina Konopleva, Ghayas C Issa, Elias Jabbour, Tapan Kadia, Courtney DiNardo, Gautam Borthakur, Naveen Pemmaraju, Nicholas J Short, Musa Yilmaz, Indraneel Deshmukh, Joie Alvarez, Sanam Loghavi, Guilin Tang, Hussein A Abbas, Michael Andreeff, Kapil Bhalla, Narasimha M Midde, Nabil · 2025
Read A phase 1/2 study of DS-1594 menin inhibitor in relapsed/refractory acute leukemias by Jayastu Senapati, Marina Konopleva, Ghayas C Issa, Elias Jabbour, Tapan Kadia, Courtney DiNardo, Gautam Borthakur, Naveen Pemmaraju, Nicholas J Short, Musa Yilmaz, Indraneel Deshmukh, Joie Alvarez, Sanam Loghavi, Guilin Tang, Hussein A Abbas, Michael Andreeff, Kapil Bhalla, Narasimha M Midde, Nabil (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12661886.txt.
Description
Jayastu Senapati, Marina Konopleva, Ghayas Issa, and a wider team wrote this clinical trial report, published in 2025. It reports the first human test of DS-1594, a menin-blocking drug for acute leukemias that had returned or resisted treatment.
Menin inhibitors attack a protein partnership that certain leukemias depend on. Seventeen adults took the drug in five rising dose groups. Most had acute myeloid leukemia, and about half carried the gene rearrangement the drug targets. A complication called differentiation syndrome appeared in five patients. No dose was chosen for the next phase. The sponsoring company stopped the trial early, citing weak results at the doses tried and a reshuffle of its portfolio. The authors publish the safety and drug-level data so the field can learn from a program that did not move forward.
Catalog record
| CREATOR | Jayastu Senapati, Marina Konopleva, Ghayas C Issa, Elias Jabbour, Tapan Kadia, Courtney DiNardo, Gautam Borthakur, Naveen Pemmaraju, Nicholas J Short, Musa Yilmaz, Indraneel Deshmukh, Joie Alvarez, Sanam Loghavi, Guilin Tang, Hussein A Abbas, Michael Andreeff, Kapil Bhalla, Narasimha M Midde, Nabil |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |