Isoliquiritigenin ameliorates Parkinson’s disease via gut microbiota remodeling: potential mediating role of Parabacteroides distasonis
Mengyun Li, Xiaobing Zhang, Jiafeng Lu, Junjie Xiang, Jie Wu, Matao Zheng, Siwei Yang, Lingyan He, Xian Shao · 2025
Read Isoliquiritigenin ameliorates Parkinson’s disease via gut microbiota remodeling: potential mediating role of Parabacteroides distasonis by Mengyun Li, Xiaobing Zhang, Jiafeng Lu, Junjie Xiang, Jie Wu, Matao Zheng, Siwei Yang, Lingyan He, Xian Shao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12661803.txt.
Description
Mengyun Li and co-authors test a licorice compound against Parkinson's disease through the gut, in a 2025 study. The compound, isoliquiritigenin, already shows nerve protection; whether it works by reshaping gut microbes was unknown. Mice with chemical induced Parkinson's received it by mouth, and some got gut transplants from treated donors.
Treated and transplanted mice moved better and kept more dopamine neurons. The compound cut pro swelling gut genera and boosted a bacterium called Parabacteroides distasonis. Feeding that live bacterium alone copied the full benefit, while heat killed bacteria did not. Gut barrier and brain swelling measures improved alongside.
Catalog record
| CREATOR | Mengyun Li, Xiaobing Zhang, Jiafeng Lu, Junjie Xiang, Jie Wu, Matao Zheng, Siwei Yang, Lingyan He, Xian Shao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |