Integrative multi-omics and single-cell transcriptomics reveal ARHGEF12 driving chemoresistance in bladder cancer
Kunyao Zhu, Zhejiao Zhang, Tinghao Li, Yan Sun, Junlong Zhu, Linfeng Wu, Xiaoyu Zhang, Hang Tong, Zijia Qin, Aimin Wang, Weiyang He · 2025
Read Integrative multi-omics and single-cell transcriptomics reveal ARHGEF12 driving chemoresistance in bladder cancer by Kunyao Zhu, Zhejiao Zhang, Tinghao Li, Yan Sun, Junlong Zhu, Linfeng Wu, Xiaoyu Zhang, Hang Tong, Zijia Qin, Aimin Wang, Weiyang He (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12661753.txt.
Description
A peer-reviewed research article from Europe PMC (2025). Bladder cancer (BLCA) is the predominant type of urothelial carcinoma in urinary system, and resistance to cisplatin-based chemotherapy substantially worsens clinical outcomes, presenting a major therapeutic obstacle. In this study, we integrated genome-wide association study (GWAS) data with expression quantitative trait loci (eQTL) analyses, and applied Mendelian randomization (MR) to assess the causal effects of eQTLs from 19,942 genes on BLCA.
Catalog record
| CREATOR | Kunyao Zhu, Zhejiao Zhang, Tinghao Li, Yan Sun, Junlong Zhu, Linfeng Wu, Xiaoyu Zhang, Hang Tong, Zijia Qin, Aimin Wang, Weiyang He |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |