One-pot CuI/l-proline-catalysed multicomponent synthesis of pyrido[2′,1′:2,3]imidazo[4,5-c]quinoline derivatives from 2-(2-bromophenyl)imidazo[1,2-a]pyridines, NH3 and DMSO under air
Ban Van Phuc, Dinh Thi Thuy, Phuong Anh Dao, Van Loc Nguyen, Van Ha Nguyen, Hung Huy Nguyen, Dang Van Do, Hien Nguyen, Tran Quang Hung, Tuan Thanh Dang · 2025
Read One-pot CuI/l-proline-catalysed multicomponent synthesis of pyrido[2′,1′:2,3]imidazo[4,5-c]quinoline derivatives from 2-(2-bromophenyl)imidazo[1,2-a]pyridines, NH3 and DMSO under air by Ban Van Phuc, Dinh Thi Thuy, Phuong Anh Dao, Van Loc Nguyen, Van Ha Nguyen, Hung Huy Nguyen, Dang Van Do, Hien Nguyen, Tran Quang Hung, Tuan Thanh Dang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12661392.txt.
Description
Ban Van Phuc leads a ten-author team reporting a one-pot route to complex fused ring compounds, in a chemistry paper published in two thousand twenty-five. The products, long-named pyrido-imidazo-quinolines, belong to families prized in medicinal chemistry. Building them usually takes several steps.
Their method starts from brominated imidazopyridines, ammonia, and the solvent DMSO, open to air. A copper iodide and proline catalyst first couples carbon to nitrogen. Air oxidation then closes the final ring in the same pot. Yields were high across a series of derivatives. The same trick produced sulfur-containing cousins in good yields. Fewer steps and cheap catalysts make the route attractive for library synthesis in drug discovery.
Catalog record
| CREATOR | Ban Van Phuc, Dinh Thi Thuy, Phuong Anh Dao, Van Loc Nguyen, Van Ha Nguyen, Hung Huy Nguyen, Dang Van Do, Hien Nguyen, Tran Quang Hung, Tuan Thanh Dang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |