Acute radiotoxicity studies and safety assessment of 166Ho-EDTMP and 166Ho-DOTMP for the palliative treatment of bone metastases
Ho Hong Quang Dang, Thi Khanh Giang Nguyen, Thi Ngoc Nguyen, Thanh Binh Nguyen, Ngoc Bao Nam Dinh, Ngoc Dieu Thao Le, Thu Minh Chau Nguyen, Hong Ngoc Quy Dang, Van Tien Le, Thanh Nhan Nguyen, Thi Thu Nguyen · 2025
Read Acute radiotoxicity studies and safety assessment of 166Ho-EDTMP and 166Ho-DOTMP for the palliative treatment of bone metastases by Ho Hong Quang Dang, Thi Khanh Giang Nguyen, Thi Ngoc Nguyen, Thanh Binh Nguyen, Ngoc Bao Nam Dinh, Ngoc Dieu Thao Le, Thu Minh Chau Nguyen, Hong Ngoc Quy Dang, Van Tien Le, Thanh Nhan Nguyen, Thi Thu Nguyen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12661045.txt.
Description
Two radioactive compounds are used to ease pain when cancer spreads to bone, but doctors need solid safety data, especially for material made in small research reactors. Ho Hong Quang Dang and ten co-authors tested both compounds, holmium-166 joined to EDTMP and to DOTMP, in mice. They gave single very high doses to check acute poisoning over fourteen days, and treatment level doses watched over thirty days, examining blood, chemistry, and tissue samples.
The compounds were made with high purity. Even at the highest test dose, the mice showed no unexpected poisoning, and blood and tissue checks found no significant harm. Bone marrow showed slightly fewer bone building cells but active, healthy blood cell production. The results support moving these pain relieving agents toward wider clinical evaluation.
Catalog record
| CREATOR | Ho Hong Quang Dang, Thi Khanh Giang Nguyen, Thi Ngoc Nguyen, Thanh Binh Nguyen, Ngoc Bao Nam Dinh, Ngoc Dieu Thao Le, Thu Minh Chau Nguyen, Hong Ngoc Quy Dang, Van Tien Le, Thanh Nhan Nguyen, Thi Thu Nguyen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |