Pulsed electromagnetic fields inhibit atherosclerosis by regulating pyroptosis through membrane tension-mediated mechanosensitive channels
Hongxin Cheng, Qing Zhang, Wen Zhong, Hanbin Li, Lu Wang, Shiqi Wang, Chengqi He, Chenying Fu, Quan Wei · 2025
Read Pulsed electromagnetic fields inhibit atherosclerosis by regulating pyroptosis through membrane tension-mediated mechanosensitive channels by Hongxin Cheng, Qing Zhang, Wen Zhong, Hanbin Li, Lu Wang, Shiqi Wang, Chengqi He, Chenying Fu, Quan Wei (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12660931.txt.
Description
Hongxin Cheng and co-authors show that pulsed electromagnetic fields slow artery plaque growth in mice, in a 2025 study. Plaque buildup underlies most heart and brain vessel disease. Standard drugs and stents carry side effects or limits. The fields are noninvasive and calm inflammation. The team used mice bred to develop plaques. Some lacked a key inflammation switch gene. Human vessel cells and patient blood samples joined the work.
Inflammatory cell death, called pyroptosis, marked disease progress. The fields suppressed the inflammasome that drives it. Plaque formation shrank and progression slowed. Blood protein scans showed the same death signals raised in patients. Membrane proteins changed most clearly. The mechanism runs through membrane tension. Fields tune a tension-sensing channel, easing cell power failure. Less death of vessel lining cells followed. The authors offer a new physical route against plaque disease.
Catalog record
| CREATOR | Hongxin Cheng, Qing Zhang, Wen Zhong, Hanbin Li, Lu Wang, Shiqi Wang, Chengqi He, Chenying Fu, Quan Wei |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |