Localized Wnt-signaling promotes asymmetric NuMA-dependent oriented divisions and unequal apportioning of mitochondria
Susanna Eli, Greta Rauso, Paola Ghezzi, James L. A. Szczerkowski, Michela Bruzzi, Francesca Rizzelli, Fabiola Iommazzo, Alessia Loffreda, Francesco Castagna, Federico Donà, Chiara Gaddoni, Ambra Dondi, Mattia Marenda, Simona Rodighiero, Pierre Tournier, Zeno Lavagnino, Dario Parazzoli, Nils C. Gauth · 2025
Read Localized Wnt-signaling promotes asymmetric NuMA-dependent oriented divisions and unequal apportioning of mitochondria by Susanna Eli, Greta Rauso, Paola Ghezzi, James L. A. Szczerkowski, Michela Bruzzi, Francesca Rizzelli, Fabiola Iommazzo, Alessia Loffreda, Francesco Castagna, Federico Donà, Chiara Gaddoni, Ambra Dondi, Mattia Marenda, Simona Rodighiero, Pierre Tournier, Zeno Lavagnino, Dario Parazzoli, Nils C. Gauth (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12660846.txt.
Description
Susanna Eli and co-authors published a cell biology study in 2025 on how local Wnt signals steer uneven cell division and uneven sharing of mitochondria. Uneven divisions build bodies and keep tissues steady, guided by niche signals like Wnt. Using engineered Wnt niches, the team watched division machinery gather at the contact site in stem cells.
A motor complex formed with activated signal parts at the cortex, turning the spindle so division ran across the signal direction. Local signaling also steadied contractile fibers nearby. Mitochondria clustered toward the signal source and passed mostly to the nearer daughter cell, with one named protein required for that drift. Losing the Wnt co-receptor broke the uneven sharing.
Catalog record
| CREATOR | Susanna Eli, Greta Rauso, Paola Ghezzi, James L. A. Szczerkowski, Michela Bruzzi, Francesca Rizzelli, Fabiola Iommazzo, Alessia Loffreda, Francesco Castagna, Federico Donà, Chiara Gaddoni, Ambra Dondi, Mattia Marenda, Simona Rodighiero, Pierre Tournier, Zeno Lavagnino, Dario Parazzoli, Nils C. Gauth |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 120 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |