Subthalamic stimulation shifts brain network dynamics from extensive functional support to motor dominance in Parkinson’s disease
Chunguang Chu, Zhen Zhang, Jiang Wang, Yuxin Wang, Hao Ding, Muthuraman Muthuraman, Chen Liu, Chencheng Zhang · 2025
Read Subthalamic stimulation shifts brain network dynamics from extensive functional support to motor dominance in Parkinson’s disease by Chunguang Chu, Zhen Zhang, Jiang Wang, Yuxin Wang, Hao Ding, Muthuraman Muthuraman, Chen Liu, Chencheng Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12660807.txt.
Description
Chunguang Chu and seven co-authors show that deep brain stimulation reweights whole-brain network states in Parkinson's disease, beyond its local target. Stimulating the subthalamic nucleus eases motor symptoms, but how it reshapes global brain dynamics was little known. Their 2025 study first uses a pattern-finding method on scans of healthy older adults to name the brain's natural large-scale states. It then examines the timing and mix of those states in patients, with stimulation's effect in view. The balance shifts from broad support networks toward motor dominance.
A global account explains side effects and benefits that a local story misses. Network states give a common language for comparing patients and settings. The authors bridge a device therapy and systems neuroscience. Their analysis treats stimulation as a state-shifting intervention. The work may guide programming of stimulators by network goals, not only by symptoms.
Catalog record
| CREATOR | Chunguang Chu, Zhen Zhang, Jiang Wang, Yuxin Wang, Hao Ding, Muthuraman Muthuraman, Chen Liu, Chencheng Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |