Macrophages in obesity-related breast cancer: mechanistic insights and therapeutic opportunities
Huiyu Dong, Ming Zhou, Qin Sun, Yixing Ren, Lunkun Ma · 2025
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Description
A peer-reviewed research article from Europe PMC (2025). Obesity has emerged as a global public health crisis, significantly increasing susceptibility to malignancies, including breast cancer. In the context of Obesity-Related Breast Cancer (ORBC), the abundant adipose tissue in the mammary gland profoundly reshapes the tumor microenvironment (TME). Whereas obesity drives chronic, low-grade inflammation through pro-inflammatory M1 adipose tissue macrophages (ATMs), tumor-associated macrophages (TAMs) acquire a predominantly immunosuppressive M2 phenotype that promotes angiogenesis, immune evasion, and treatment resistance.
Catalog record
| CREATOR | Huiyu Dong, Ming Zhou, Qin Sun, Yixing Ren, Lunkun Ma |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |