ACA kills Mycobacterium tuberculosis and M. bovis by targeting cell wall core assembling protein CpsA
Feng Huang, Mengcong Shi, Liu Chen, Xiaohui Li, Zixin Wang, Dong Jiang, Junfeng Chen, Hua Zhang, Zheng-Guo He · 2025
Read ACA kills Mycobacterium tuberculosis and M. bovis by targeting cell wall core assembling protein CpsA by Feng Huang, Mengcong Shi, Liu Chen, Xiaohui Li, Zixin Wang, Dong Jiang, Junfeng Chen, Hua Zhang, Zheng-Guo He (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12658130.txt.
Description
Tuberculosis (TB), caused by Mycobacterium tuberculosis, still globally threatens human health. With the emergence of multidrug-resistant strains, there is an imperative need to discover new anti-TB agents and identify novel drug targets. Here, we report that the compound ACA, namely 3-azidothiophene-2-carboxylic acid, can kill M. tuberculosis by targeting the bacterial cell wall core assembling process.
Catalog record
| CREATOR | Feng Huang, Mengcong Shi, Liu Chen, Xiaohui Li, Zixin Wang, Dong Jiang, Junfeng Chen, Hua Zhang, Zheng-Guo He |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |