Myeloid-specific tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responses
Abhishek Guha, Robert E Sorge, Ying Si, Reed Smith, Sohail M Baig, Mohammed Amir Husain, Stacie K Totsch, Ava M Piper, Perry J Blackshear, Peter H King · 2025
Read Myeloid-specific tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responses by Abhishek Guha, Robert E Sorge, Ying Si, Reed Smith, Sohail M Baig, Mohammed Amir Husain, Stacie K Totsch, Ava M Piper, Perry J Blackshear, Peter H King (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12657561.txt.
Description
A peer-reviewed research article from Europe PMC (2025). BackgroundProinflammatory mediators including COX-2, IL-1β, IL-6, and TNF-α, play major roles in the initiation of postsurgical pain. Produced primarily by activated macrophages and microglia, these mediators drive hyperexcitation of nociceptors and promote peripheral and central pain sensitization. Post-transcriptional RNA regulation is a major control point for these mediators, centering around adenine- and uridine-rich elements (ARE) in the 3’ untranslated regions of their mRNA transcripts. The ARE governs RNA stability and translational efficiency through an interaction with ARE-specific RNA binding proteins (AUBP).
Catalog record
| CREATOR | Abhishek Guha, Robert E Sorge, Ying Si, Reed Smith, Sohail M Baig, Mohammed Amir Husain, Stacie K Totsch, Ava M Piper, Perry J Blackshear, Peter H King |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |