Aerobic Exercise Improves Cognitive Recovery in Mice with Chronic Cerebral Hypoperfusion by Modulating the Annexin-A1-MAPK Axis and Astrocyte Polarization
Wei Zhang, Jing He, Yuxin Wang, Xiaozhen Wang, He Jin, Xu Zhang, Ling Kong, Yanchuan Wu, Yong Yang, Rong Wang · 2025
Read Aerobic Exercise Improves Cognitive Recovery in Mice with Chronic Cerebral Hypoperfusion by Modulating the Annexin-A1-MAPK Axis and Astrocyte Polarization by Wei Zhang, Jing He, Yuxin Wang, Xiaozhen Wang, He Jin, Xu Zhang, Ling Kong, Yanchuan Wu, Yong Yang, Rong Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12539550.txt.
Description
Wei Zhang and co-authors study aerobic exercise and how the brain heals in mice, in a study from 2024. Long-term low blood flow to the brain leads to vascular cognitive impairment. That state is the next most common form of dementia in the world. Exercise is known to help thought faults, but the path it takes in this case was not clear.
In mice with narrowed neck arteries, the training made spatial memory stronger. It kept white matter whole and helped the hippocampus do its work well. It slowed the fade of synaptic strengthening and raised the levels of key synaptic proteins. The training also raised a factor that calms swelling, sent out through exosomes. It calmed a key signaling axis and pushed support cells toward a state that guards the brain.
Catalog record
| CREATOR | Wei Zhang, Jing He, Yuxin Wang, Xiaozhen Wang, He Jin, Xu Zhang, Ling Kong, Yanchuan Wu, Yong Yang, Rong Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |