TBC1D15 Inhibits Autophagy of Microglia through Maintaining the Damaged Swelling Lysosome in Alzheimer’s Disease
You Wu, Yong-ming Zhou, Wei Wu, Wan-rong Jiang, Xin-yuan Zhang, Si-yuan Song, Zhao-hui Yao · 2025
Read TBC1D15 Inhibits Autophagy of Microglia through Maintaining the Damaged Swelling Lysosome in Alzheimer’s Disease by You Wu, Yong-ming Zhou, Wei Wu, Wan-rong Jiang, Xin-yuan Zhang, Si-yuan Song, Zhao-hui Yao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12539536.txt.
Description
Wu and co-authors report in 2024 that a protein called TBC1D15 holds back cleanup activity in microglia, the brain's immune cells, in Alzheimer's disease. Cleanup there clears amyloid plaques, but reports on its level over time conflict. Their work tracks that change and the protein's role in it. The head gives 2024 as the publication year.
Cleanup rose in three month old disease model mice, then fell by twelve months. The protein sat high in microglial lysosomes in the disease state. Silencing it cut cell swelling and amyloid uptake in a cell line, while raising cleanup pathways. A protein chain tied to lysosome swelling is proposed, and targeting the protein is offered as therapy logic.
Catalog record
| CREATOR | You Wu, Yong-ming Zhou, Wei Wu, Wan-rong Jiang, Xin-yuan Zhang, Si-yuan Song, Zhao-hui Yao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |