Hepatic SIRT6 protects against cholestatic liver disease primarily via inhibiting bile acid synthesis
Wen Zhang, Jiahui Wang, Luyao Yang, Yuyun Shao, Hongjun Peng, Longfeng Jiang, Liang Sheng · 2025
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Description
Bile pooled in the liver sores it slow, and one quiet gene tool in liver cells has long been tied to ease of that sore. Wen Zhang and co-authors ask which of its gifts does the work, in a study published in 2024. Mice with the tool cut from the liver alone are their test bed.
Calm of rust stress and fresh power cores, two of its famed gifts, did not lift the bile signs when bred by drugs. A drug that wakes the tool cut the bile make rate's chief step, and eased the ill. Cut that step by gene hand in the liver, and the ease held. The tool's shield, the team find, runs most through less bile made.
Catalog record
| CREATOR | Wen Zhang, Jiahui Wang, Luyao Yang, Yuyun Shao, Hongjun Peng, Longfeng Jiang, Liang Sheng |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |