Sensitivity of unconstrained quantitative magnetization transfer MRI to amyloid burden in preclinical Alzheimer’s disease
Andrew Mao, Sebastian Flassbeck, Elisa Marchetto, Arjun V. Masurkar, Henry Rusinek, Jakob Assländer · 2024
Read Sensitivity of unconstrained quantitative magnetization transfer MRI to amyloid burden in preclinical Alzheimer’s disease by Andrew Mao, Sebastian Flassbeck, Elisa Marchetto, Arjun V. Masurkar, Henry Rusinek, Jakob Assländer (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12315764.txt.
Description
Andrew Mao and five co-authors report a 2024 brain imaging study on Alzheimer's disease before symptoms begin. A scan method called magnetization transfer MRI reacts to large molecules in the brain, including the amyloid protein that builds up in this disease. The team asked whether a freer version of the method could detect amyloid in people who still think clearly.
The team scanned fifteen healthy volunteers, nine of whom showed amyloid on a separate tracer scan. Their twelve-minute scan covered the whole brain and produced measures of exchange between water and solid-like material in the tissue. Two of those measures tracked amyloid levels, while the usual measure of cortical thickness did not. The authors say the method could one day flag amyloid without tracers or contrast drugs.
Catalog record
| CREATOR | Andrew Mao, Sebastian Flassbeck, Elisa Marchetto, Arjun V. Masurkar, Henry Rusinek, Jakob Assländer |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |