Transcriptomics Insights into Targeting CK2 Complex in Cryptococcus neoformans: Implications for Large-Scale Antifungal Virtual Screening
Fadia Falah Hassan, Mohammed Hussein Mushrif, Mohammed F Hamdi, Ahmed AbdulJabbar Suleiman · 2024
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Description
Hassan and coauthors probe a kinase complex as a drug target in a fungal pathogen. The fungus causes meningitis in people with weak immunity. The kinase complex steers key cell processes in the fungus. The team used gene data to map its role in depth.
They compared gene use in normal and mutant fungal cells. Three mutant types each lacked part of the complex. Network tools mapped which proteins shift with the complex. Wide gene shifts hit growth and virulence paths. The maps flag proteins that new drugs might block. A large virtual screen can now hunt such blockers.
Catalog record
| CREATOR | Fadia Falah Hassan, Mohammed Hussein Mushrif, Mohammed F Hamdi, Ahmed AbdulJabbar Suleiman |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |