How to build the virtual cell with artificial intelligence: Priorities and opportunities
Charlotte Bunne, Yusuf Roohani, Yanay Rosen, Ankit Gupta, Xikun Zhang, Marcel Roed, Theo Alexandrov, Mohammed AlQuraishi, Patricia Brennan, Daniel B. Burkhardt, Andrea Califano, Jonah Cool, Abby F. Dernburg, Kirsty Ewing, Emily B. Fox, Matthias Haury, Amy E. Herr, Eric Horvitz, Patrick D. Hsu, Viren · 2024
Read How to build the virtual cell with artificial intelligence: Priorities and opportunities by Charlotte Bunne, Yusuf Roohani, Yanay Rosen, Ankit Gupta, Xikun Zhang, Marcel Roed, Theo Alexandrov, Mohammed AlQuraishi, Patricia Brennan, Daniel B. Burkhardt, Andrea Califano, Jonah Cool, Abby F. Dernburg, Kirsty Ewing, Emily B. Fox, Matthias Haury, Amy E. Herr, Eric Horvitz, Patrick D. Hsu, Viren (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12148494.txt.
Description
Charlotte Bunne and co-authors published a 2024 paper setting out how to build a virtual cell with artificial intelligence. A virtual cell would simulate a real cell's behavior in software, predicting its response to drugs or mutations. Traditional models capture only slices of cell life. New AI methods, fed by vast molecular measurements, promise something more complete. The paper is a roadmap, written by dozens of researchers across the field.
The authors lay out priorities: what data to gather, how to represent a cell's state, and how to train models that generalize. They stress opportunities in drug discovery and basic biology, where a good simulation could replace slow experiments. Challenges get equal time, including validation and the sheer diversity of cell types. The paper's purpose is coordination: to aim a fast-moving field at shared targets. It reads as both manifesto and work plan for a grand current project.
Catalog record
| CREATOR | Charlotte Bunne, Yusuf Roohani, Yanay Rosen, Ankit Gupta, Xikun Zhang, Marcel Roed, Theo Alexandrov, Mohammed AlQuraishi, Patricia Brennan, Daniel B. Burkhardt, Andrea Califano, Jonah Cool, Abby F. Dernburg, Kirsty Ewing, Emily B. Fox, Matthias Haury, Amy E. Herr, Eric Horvitz, Patrick D. Hsu, Viren |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |