Microbial biosynthesis of rare cannabinoids
Chunsheng Yan, Ikechukwu C Okorafor, Colin W Johnson, Kendall N Houk, Neil K Garg, Yi Tang · 2025
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Description
Chunsheng Yan and colleagues brew rare cannabis compounds in yeast, in this study from twenty twenty-four. The famous cannabinoids are abundant in the plant, but its rarer cousins, with shorter or longer side chains, can act quite differently and are nearly impossible to gather or synthesize. A microbe factory could supply them for study.
The team rebuilt baker's yeast to stockpile a key precursor, imported a fungal pathway for the acid building blocks, and added the enzymes that finish the molecules. The yeast produced two rare cannabinoid acids from plain sugar, in milligram-per-liter amounts. Heating one gave the potent compound known as THCP. Because fungi offer many related pathway variants, the authors say the platform could yield other rare, and even brand-new, cannabinoids for pharmacology to explore.
Catalog record
| CREATOR | Chunsheng Yan, Ikechukwu C Okorafor, Colin W Johnson, Kendall N Houk, Neil K Garg, Yi Tang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |