P53 and Ki67 Biomarkers are Predictors for Malignant Transformation in Oral Submucous Fibrosis: A Prospective Study
KA Kamala, S Sankethguddad · 2024
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Description
Kamala and Sankethguddad test whether two cell proteins can flag which mouth lesions are heading toward cancer. Oral submucous fibrosis stiffens the mouth's lining and turns malignant at a worrying rate. The proteins, p53 and Ki67, both mark cell proliferation and appear early in oral cancer. The team stained tissue from 60 fibrosis patients, 60 oral cancer patients as a positive comparison, and 60 samples of normal mouth lining.
Both proteins showed far more strongly in fibrosis tissue than in normal lining, though less than in outright cancer. Their levels also lined up significantly with patients' ages, sex, and chewing habits, the habit being a known driver of the disease. The authors conclude that checking these two markers could help catch dangerous change early in high-risk fibrosis patients, when treatment is most effective.
Catalog record
| CREATOR | KA Kamala, S Sankethguddad |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |