AMPKα2调控IRE1α-JNK通路介导代谢功能障碍相关脂肪性肝病的作用
Shujie ZHAO, Weilun FANG, Yu WEI, Jiahui MENG, Qiao JIN, Weijin FANG, 敏宁 彭 · 2024
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Description
Fatty liver disease tied to metabolic dysfunction now affects a quarter of the world's people, and the authors probe one suspected driver: stress inside the liver cell's protein factory. Their focus is AMPK alpha2, an energy-sensing enzyme, and a stress pathway running through the IRE1 alpha and JNK proteins. They bred mice lacking the enzyme only in the liver and fed them a high-fat diet for twelve weeks alongside normal controls. Blood sugar, liver enzymes, fat staining, and protein readouts tracked the damage and the pathway's activity.
In the visible results, the high-fat diet alone raised blood sugar and the liver injury markers ALT and AST in normal mice. The authors use the knockout comparison to test whether the enzyme restrains that stress pathway, and with it the disease.
Catalog record
| CREATOR | Shujie ZHAO, Weilun FANG, Yu WEI, Jiahui MENG, Qiao JIN, Weijin FANG, 敏宁 彭 |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |