The art of war: using genetic insights to understand and harness radiation sensitivity in hematologic malignancies
N. Ari Wijetunga, Joachim Yahalom, Brandon S. Imber · 2025
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Description
Ari Wijetunga, Joachim Yahalom, and Brandon Imber review radiation sensitivity in blood cancers in a 2024 paper. These cancers often melt under far lower radiation doses than solid tumors need. The review gathers what gene studies now say about why. Mutations in repair genes like TP53 and ATM stand at the center of the story.
The authors trace how the field learned this sensitivity, from early observation to gene level proof. Each repair flaw hints at a dose or drug pairing tuned to it. The aim is personal radiation oncology: right dose for the tumor's own wiring. The review gives clinicians a gene map for a trait they have used by feel for decades.
Catalog record
| CREATOR | N. Ari Wijetunga, Joachim Yahalom, Brandon S. Imber |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |