Intermediate risk prostate tumors contain lethal subtypes
William L. Harryman, James P. Hinton, Rafael Sainz, Jaime M. C. Gard, John M. Ryniawec, Gregory C. Rogers, Noel A. Warfel, Beatrice S. Knudsen, Raymond B. Nagle, Juan J. Chipollini, Benjamin R. Lee, Belinda L. Sun, Anne E. Cress · 2025
Read Intermediate risk prostate tumors contain lethal subtypes by William L. Harryman, James P. Hinton, Rafael Sainz, Jaime M. C. Gard, John M. Ryniawec, Gregory C. Rogers, Noel A. Warfel, Beatrice S. Knudsen, Raymond B. Nagle, Juan J. Chipollini, Benjamin R. Lee, Belinda L. Sun, Anne E. Cress (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11932713.txt.
Description
William L Harryman and co-authors warn that mid-grade prostate tumors can hide killers. Their 2024 paper focuses on intermediate risk prostate cancer, most of it managed with surveillance, radiation, or surgery, and on two subtypes buried inside that label: cribriform architecture and intraductal carcinoma.
Both subtypes carry more metastasis, recurrence, and death, yet biopsy misses them up to half the time, and even guided sampling catches barely half. Finding either one can disqualify a man from surveillance. The authors argue the field needs sharper detection, from molecular study of the subtypes to AI-read pathology and live microscopy of surgical tissue. Matching each hidden subtype to its best treatment, they say, could stop quiet tumors from becoming high-risk disease.
Catalog record
| CREATOR | William L. Harryman, James P. Hinton, Rafael Sainz, Jaime M. C. Gard, John M. Ryniawec, Gregory C. Rogers, Noel A. Warfel, Beatrice S. Knudsen, Raymond B. Nagle, Juan J. Chipollini, Benjamin R. Lee, Belinda L. Sun, Anne E. Cress |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |