Integrated transcriptomic and metabolomic analysis reveals the effects of EMMPRIN on nucleotide metabolism and 1C metabolism in AS mouse BMDMs
Yun Zhang, Diyuan Zhang, Zulong Xie, Tianli Xia, Lili Zou, Tao Wang, Li Zhong, Zhuo Zeng, Lingying Wang, Guozhu Chen, Xing Liang · 2025
Read Integrated transcriptomic and metabolomic analysis reveals the effects of EMMPRIN on nucleotide metabolism and 1C metabolism in AS mouse BMDMs by Yun Zhang, Diyuan Zhang, Zulong Xie, Tianli Xia, Lili Zou, Tao Wang, Li Zhong, Zhuo Zeng, Lingying Wang, Guozhu Chen, Xing Liang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11927532.txt.
Description
Yun Zhang and co-authors probe how a protein that aids artery plaque growth reshapes cell chemistry, in a study published in two thousand twenty-four. The protein is a known promoter of the artery disease. Mice prone to plaques had the protein silenced in their immune cells, and both gene and chemical profiles were read.
Thousands of genes and chemical products shifted after silencing. Two pathways stood out at both levels: building blocks for DNA and a carbon-shuffling pathway key to cell growth. Key genes in those paths moved in telling directions. Treated cells grew slower and stalled at a cell-cycle gate. Sugar and fat handling also changed.
Catalog record
| CREATOR | Yun Zhang, Diyuan Zhang, Zulong Xie, Tianli Xia, Lili Zou, Tao Wang, Li Zhong, Zhuo Zeng, Lingying Wang, Guozhu Chen, Xing Liang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |