Editorial: Graft-versus leukemia (GVL) effect - immunobiology and ways to augment it
Mahasweta Gooptu · 2025
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Description
Mahasweta Gooptu, writing alone, introduces a review series on the graft-versus-leukemia effect in a 2025 editorial. After a stem cell transplant from a donor, the new immune system can attack leftover leukemia, which helps cure the disease. Relapse, when that attack fails, is now the chief cause of transplant failure.
The editorial previews reviews on pulling the helpful effect apart from graft-versus-host disease, the harmful attack on healthy tissue. Topics include therapies that calm immunity only where needed, steering T cells toward the bone marrow, and blocking the ways leukemia hides from immune attack. One review covers regulatory T cells, which may ease the harmful attack while sparing the helpful one. Another looks at cell metabolism in the fight.
Catalog record
| CREATOR | Mahasweta Gooptu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 6 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |