In Silico toxicity assessment of Euphorbia hirta
Prabhu Subramani, Senthil Murugappan, Gajalakshm Ganeshi, Sumathi Jones, Devi Mani · 2024
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Description
Prabhu Subramani and four co-authors present a 2024 computer-based safety screen of Euphorbia hirta, a tropical weed used in folk medicine. As drug resistance grows, herbs are being checked as sources of new antibiotics. Before any drug path, a plant's compounds must pass toxicity checks. The team used a software tool that predicts how toxic each compound is to aquatic life, a standard early warning test.
The screen covered the plant's known chemical constituents, from fatty acids to plant sterols. Model estimates were combined into a consensus value for each compound. All listed constituents came out as nontoxic under the tool's thresholds. The authors conclude the plant's chemicals sit within acceptable toxicity limits for drug development. They frame the result as a green light for preclinical and clinical study, not as proof of safety in people.
Catalog record
| CREATOR | Prabhu Subramani, Senthil Murugappan, Gajalakshm Ganeshi, Sumathi Jones, Devi Mani |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 11 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |