Cynaroside: a potential therapeutic agent targeting arachidonate 15-lipoxygenase to mitigate cerebral ischemia/reperfusion injury
Wenpeng Cao, Yufeng Hu, Xingyu Yu, Tingting Long, Baofei Sun, Shan Lei, Peng Xie, Wenfeng Yu · 2025
Read Cynaroside: a potential therapeutic agent targeting arachidonate 15-lipoxygenase to mitigate cerebral ischemia/reperfusion injury by Wenpeng Cao, Yufeng Hu, Xingyu Yu, Tingting Long, Baofei Sun, Shan Lei, Peng Xie, Wenfeng Yu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11867947.txt.
Description
Wenpeng Cao and colleagues test a plant flavonoid against stroke damage in mice, tracing its target, in this study from twenty twenty-four. The compound is cynaroside, known for calming inflammation and oxidation. The injury modeled is the harm done when blood flow returns to a blocked brain artery.
Treated mice woke from the model stroke with milder deficits, smaller dead zones, and less swelling, and their brain immune cells stayed calmer. Computer docking and binding tests pointed to one target: Alox15, an enzyme the compound appears to grip directly. With it suppressed, the inflammatory alarm chain quieted and the markers of ferroptosis, an iron-driven cell death, fell. Toxin signals such as interleukin-1 beta dropped in both mouse brains and dish-grown immune cells. The authors propose cynaroside as a stroke candidate working through this enzyme.
Catalog record
| CREATOR | Wenpeng Cao, Yufeng Hu, Xingyu Yu, Tingting Long, Baofei Sun, Shan Lei, Peng Xie, Wenfeng Yu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |