PINK1/PARKIN-mediated mitophagy inhibits the interferon response and promotes viral replication during Pseudorabies virus infection
Yuan Zhao, Zhenbang Zhu, Wenqiang Wang, Zhendong Zhang, Wei Wen, Xiangdong Li · 2024
Read PINK1/PARKIN-mediated mitophagy inhibits the interferon response and promotes viral replication during Pseudorabies virus infection by Yuan Zhao, Zhenbang Zhu, Wenqiang Wang, Zhendong Zhang, Wei Wen, Xiangdong Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11864696.txt.
Description
Yuan Zhao and co-authors show how a pig virus disarms the cell's alarm system in this 2024 study. Pseudorabies virus harms pigs worldwide. Infected cells start eating their own damaged mitochondria, a cleanup called mitophagy, driven by two proteins named PINK1 and PARKIN.
The team found the virus pushes that cleanup on purpose. The cleanup destroys a signaling protein on the mitochondria that normally triggers interferon, the cell's antiviral shout. With the shout silenced, the virus copies itself more freely. Blocking the cleanup path is thus a candidate defense for farms. The study maps a full chain from infection to immune escape, a useful target list for drug and vaccine design.
Catalog record
| CREATOR | Yuan Zhao, Zhenbang Zhu, Wenqiang Wang, Zhendong Zhang, Wei Wen, Xiangdong Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |