Mechanistic Perspective on C–N and C–S Bond Construction Catalyzed by Cytochrome P450 Enzymes
Tai-Ping Zhou, Yakun Fan, Jinyan Zhang, Binju Wang · 2024
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Description
Tai-Ping Zhou and co-authors review in 2024 how a family of enzymes builds certain chemical bonds in natural products. The enzymes are called cytochrome P450s. They drive many steps that shape drugs and other useful compounds found in nature.
Recent work shows these enzymes can form bonds between carbon and nitrogen, and carbon and sulfur. How they do so is still not clear. The review uses theory and computer models to trace the steps. Shape changes in midway forms, shaped by the enzyme, seem to guide the result. The findings may help design better enzyme tools.
Catalog record
| CREATOR | Tai-Ping Zhou, Yakun Fan, Jinyan Zhang, Binju Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |