A functional SNP of the core promoter region within goat CDC25A gene affects litter size
Taiyuan Zhang, Jingxuan Wang, Yangyang Bai, Qian Wang, Ke Wang, Haijing Zhu, Lei Qu, Zhengang Guo, Chuanying Pan, Xianyong Lan · 2025
Read A functional SNP of the core promoter region within goat CDC25A gene affects litter size by Taiyuan Zhang, Jingxuan Wang, Yangyang Bai, Qian Wang, Ke Wang, Haijing Zhu, Lei Qu, Zhengang Guo, Chuanying Pan, Xianyong Lan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11841496.txt.
Description
Taiyuan Zhang and nine co-authors find a single-letter gene change that affects litter size in goats. Their study was published in twenty twenty-four. The gene, CDC25A, drives cell division and was already a candidate for breeding traits.
The team first mapped the gene's core switch region with light-reporting tests in cells. A variant inside that switch was then found by sequencing and typed in over one thousand goats. One letter version made the switch work harder. Goats carrying two copies of that version had clearly larger litters than the others. The matching pattern between switch strength and litter size supports a real effect. The marker could help breeders pick goats that kid more offspring.
Catalog record
| CREATOR | Taiyuan Zhang, Jingxuan Wang, Yangyang Bai, Qian Wang, Ke Wang, Haijing Zhu, Lei Qu, Zhengang Guo, Chuanying Pan, Xianyong Lan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |