Combined metabolomics and 16S rDNA sequence analyses of the gut microbiome reveal the action mechanism of Fructus Akebiae against hepatic fibrosis
Rong-Rong Wu, Duo-Rui Nie, Fang-Hui He, Zhi-Hang Li, Fei Xu · 2025
Read Combined metabolomics and 16S rDNA sequence analyses of the gut microbiome reveal the action mechanism of Fructus Akebiae against hepatic fibrosis by Rong-Rong Wu, Duo-Rui Nie, Fang-Hui He, Zhi-Hang Li, Fei Xu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11835924.txt.
Description
Wu, Nie, He, Li, and Xu ran a mouse study in twenty twenty-four. They tested a fruit extract against liver fibrosis. The fruit, Fructus Akebiae, is used in Chinese medicine. The team scarred the livers of mice with a toxic chemical. Groups of mice got the extract at three dose levels. Staff tracked tissue change and key scarring markers. They paired gut microbe reads with liver chemical profiles. Computer maps added guesses at the targets hit.
The extract clearly eased liver scarring in treated mice. It rebalanced gut microbes, raising a helpful Akkermansia group. Liver chemical profiles moved back toward normal sugar handling. Some microbes tracked closely with set sugar chemicals. Guessed targets centered on swelling and cell death paths. The team puts it forward as a strong treatment hope.
Catalog record
| CREATOR | Rong-Rong Wu, Duo-Rui Nie, Fang-Hui He, Zhi-Hang Li, Fei Xu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |