Attenuation of acute kidney injury in a murine model of neonatal Escherichia coli sepsis
Esther M. Speer, Atilade A. Adedeji, Joyce Lin, Alexandra Khorasanchi, Asma Rasheed, Maya Bhat, Kelly Mackenzie, Randolph Hennigar, Kimberly J. Reidy, Robert P. Woroniecki · 2025
Read Attenuation of acute kidney injury in a murine model of neonatal Escherichia coli sepsis by Esther M. Speer, Atilade A. Adedeji, Joyce Lin, Alexandra Khorasanchi, Asma Rasheed, Maya Bhat, Kelly Mackenzie, Randolph Hennigar, Kimberly J. Reidy, Robert P. Woroniecki (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11830670.txt.
Description
Esther Speer and nine colleagues test whether adding the drug pentoxifylline to antibiotics reduces kidney injury in newborn mice with sepsis. Sepsis often damages kidneys in newborns, and no effective treatment exists. Day-old mouse pups were infected with Escherichia coli bacteria. They then got saline, one of two antibiotics, or antibiotics plus pentoxifylline.
Infected pups showed strong signs of kidney inflammation and injury. The combined treatment dampened chemokines, inflammatory messengers, and markers of tube injury in blood and kidney tissue. Some effects differed by sex. Microscopy of injury markers matched the chemistry. The authors conclude the pairing may soften sepsis-related kidney injury and deserves further study.
Catalog record
| CREATOR | Esther M. Speer, Atilade A. Adedeji, Joyce Lin, Alexandra Khorasanchi, Asma Rasheed, Maya Bhat, Kelly Mackenzie, Randolph Hennigar, Kimberly J. Reidy, Robert P. Woroniecki |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |