Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model
Tala Curry-Koski, Liam P. Curtin, Mitra Esfandiarei, Theresa Currier Thomas · 2025
Read Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model by Tala Curry-Koski, Liam P. Curtin, Mitra Esfandiarei, Theresa Currier Thomas (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11825817.txt.
Description
Curry-Koski and three co-authors find early brain age marks in a mouse line bred for a weak-weave ill in this twenty twenty-five study. The ill springs from a flaw in a fiber gene and can swell the main heart vein with age. Brain vein health in the ill has had scant study till now.
Inside, mice of six months with the flaw were set next to sound mice of six and twelve months. The flawed young mice showed thin small-vessel nets in the brain's mem zone, like old sound mice. Their brain gate leaked more in two of the three zones checked. Guard cell counts in that zone also ran high, a sign of brain swelling. The set marks an early-age brain in the ill line.
Catalog record
| CREATOR | Tala Curry-Koski, Liam P. Curtin, Mitra Esfandiarei, Theresa Currier Thomas |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |