Establishing rabbit critical-size bone defects to evaluate the bone-regeneration potential of porous calcium phosphate ceramics
Wei Lei, Yan Wu, Hao Yuan, Ping He, Jingqi Wu, Jingrong Chen, Yuxiao Liu, Hongmei Zhang, Joost D. de Bruijn, Xuerong Xiang, Ping Ji, Huipin Yuan, Mingzheng Li · 2025
Read Establishing rabbit critical-size bone defects to evaluate the bone-regeneration potential of porous calcium phosphate ceramics by Wei Lei, Yan Wu, Hao Yuan, Ping He, Jingqi Wu, Jingrong Chen, Yuxiao Liu, Hongmei Zhang, Joost D. de Bruijn, Xuerong Xiang, Ping Ji, Huipin Yuan, Mingzheng Li (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11813868.txt.
Description
Wei Lei and co-authors published this study in 2024. It sets up rabbit models of critical-size bone defects: holes in bone too large to heal on their own. Such models are the standard test bed for materials that claim to regrow bone, here porous calcium phosphate ceramics.
The team made round holes in rabbit skulls and long gaps in forearm bones, then filled some with ceramic implants. A skull hole of 12.6 millimeters still had not healed after twelve weeks, which confirmed the model. One ceramic mix, with a finer surface, grew much more new bone than a coarser rival. In the forearm, four of five implants bridged the gap by twenty-four weeks. The work gives other labs two checked models for testing bone substitutes.
Catalog record
| CREATOR | Wei Lei, Yan Wu, Hao Yuan, Ping He, Jingqi Wu, Jingrong Chen, Yuxiao Liu, Hongmei Zhang, Joost D. de Bruijn, Xuerong Xiang, Ping Ji, Huipin Yuan, Mingzheng Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |