Transcriptomic signatures of severe acute mountain sickness during rapid ascent to 4,300 m
Ruoting Yang, Aarti Gautam, Rasha Hammamieh, Robert C. Roach, Beth A. Beidleman · 2025
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Description
Ruoting Yang and co-authors hunt gene signatures of mountain sickness in a 2025 paper. Rapid ascent to high altitude can trigger acute mountain sickness in unacclimatized people. The team profiled blood gene activity at sea level and at 4,300 meters.
Two separate cohorts took part, guarding against flukes. At altitude, hemoglobin genes and one other gene split those who fell sick from those who did not. A key pathway answered differently at the two heights, hinting at adaptation. The authors propose marker panels to diagnose sickness at altitude and to predict, from sea-level blood, who is at risk.
Catalog record
| CREATOR | Ruoting Yang, Aarti Gautam, Rasha Hammamieh, Robert C. Roach, Beth A. Beidleman |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |