Candidate SNP markers of changes in the expression levels of the human SCN9A gene as a hub gene for pain generation, perception, response and anesthesia
P.A. Dotsenko, K.A. Zolotareva, R.A. Ivanov, I.V. Chadaeva, N.L. Podkolodnyy, V.A. Ivanisenko, P.S. Demenkov, S.A. Lashin, M.P. Ponomarenko · 2024
Read Candidate SNP markers of changes in the expression levels of the human SCN9A gene as a hub gene for pain generation, perception, response and anesthesia by P.A. Dotsenko, K.A. Zolotareva, R.A. Ivanov, I.V. Chadaeva, N.L. Podkolodnyy, V.A. Ivanisenko, P.S. Demenkov, S.A. Lashin, M.P. Ponomarenko (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11813798.txt.
Description
Nine authors hunt gene markers tied to pain in this 2024 study. They scan 568 human genes linked to pain generation, perception, response, and anesthesia, hunting for one gene that sits at the hub of all four.
One gene, SCN9A, stood alone at that hub. It codes a sodium channel in sensory neurons that carries damage signals to the central nervous system. The team dated the genes on an evolutionary scale and mapped how channel phosphorylation sits at the center of pain networks. They then nominate single letter DNA changes that may shift how strongly the hub gene is expressed, as candidate markers for pain studies.
Catalog record
| CREATOR | P.A. Dotsenko, K.A. Zolotareva, R.A. Ivanov, I.V. Chadaeva, N.L. Podkolodnyy, V.A. Ivanisenko, P.S. Demenkov, S.A. Lashin, M.P. Ponomarenko |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |