Aging, cancer, and autophagy: connections and therapeutic perspectives
Begoña Zapatería, Esperanza Arias · 2025
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Description
Begoña Zapatería and Esperanza Arias review how aging, cancer, and the cell's recycling system feed into one another. Their 2024 paper notes that age brings cell stress, unstable genomes, and a buildup of worn-out cells, all of which favor cancer. The recycling process, autophagy, sits at the center of this triangle.
Early on, autophagy guards against cancer by clearing damaged parts before they cause harm. Later, established tumors hijack the same process to survive hunger and shrug off treatment. The review follows these links through tumor growth, cell aging, and failing protein control. The authors argue that drugs aimed at autophagy could serve both cancer care and healthy aging, if timed to which role the process is playing.
Catalog record
| CREATOR | Begoña Zapatería, Esperanza Arias |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |