Joint Regional Uptake Quantification of Thorium-227 and Radium-223 Using a Multiple-Energy-Window Projection-Domain Quantitative SPECT Method
Zekun Li, Nadia Benabdallah, Richard Laforest, Richard L Wahl, Daniel L J Thorek, Abhinav K Jha · 2024
Read Joint Regional Uptake Quantification of Thorium-227 and Radium-223 Using a Multiple-Energy-Window Projection-Domain Quantitative SPECT Method by Zekun Li, Nadia Benabdallah, Richard Laforest, Richard L Wahl, Daniel L J Thorek, Abhinav K Jha (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11807287.txt.
Description
Alpha-particle therapies aim radiation at tumors from inside the body, and two isotopes share the work: thorium-227, the drug's payload, and its decay product radium-223, which wanders after release. Zekun Li and co-authors build a method to measure how much of each isotope sits in each region of a patient, using SPECT scans that catch the faint photons both isotopes emit.
The task is hard: counts are tiny, the isotopes' photon peaks overlap, and ordinary reconstruction blurs. Their method reads the raw projection data across several energy windows at once and estimates both uptakes jointly. In digital phantom studies, including a virtual trial styled on prostate cancer spread to bone, the estimates proved accurate and precise, beating current methods across lesion sizes and contrasts. The results held up under uneven uptake inside regions and small errors in region outlines, and the spread of estimates neared the theoretical best.
Catalog record
| CREATOR | Zekun Li, Nadia Benabdallah, Richard Laforest, Richard L Wahl, Daniel L J Thorek, Abhinav K Jha |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |