Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia
Ruihua Ma, Andrew D Prigge, Tatiana P Ortiz Serrano, Yuan Cheng, Jennifer M Davis, Karen F Lou, Walter A Wood, Hanh Chi Do, Ziyou Ren, McKenzie M Fulcer, Mary J Lotesto, Benjamin D Singer, Bria M Coates, Karen M Ridge · 2024
Read Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia by Ruihua Ma, Andrew D Prigge, Tatiana P Ortiz Serrano, Yuan Cheng, Jennifer M Davis, Karen F Lou, Walter A Wood, Hanh Chi Do, Ziyou Ren, McKenzie M Fulcer, Mary J Lotesto, Benjamin D Singer, Bria M Coates, Karen M Ridge (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11804169.txt.
Description
Ma and co-authors show in 2024 that the protein vimentin weakens regulatory T cells after viral pneumonia, by trapping a receptor at the cell's distal pole. These T cells calm inflammation and repair lung tissue. Deleting vimentin only in those cells changed the disease course in mice.
Mice without T cell vimentin carried more of a repair ready T cell type, suppressed inflammatory cells, and survived influenza lung injury better. Vimentin holds an interleukin receptor at the pole complex, away from its ligand, which cuts output of a repair factor. The authors propose the pole complex as a drug switch to boost repair in severe viral pneumonia.
Catalog record
| CREATOR | Ruihua Ma, Andrew D Prigge, Tatiana P Ortiz Serrano, Yuan Cheng, Jennifer M Davis, Karen F Lou, Walter A Wood, Hanh Chi Do, Ziyou Ren, McKenzie M Fulcer, Mary J Lotesto, Benjamin D Singer, Bria M Coates, Karen M Ridge |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |