Clinical assessment and transcriptome analysis of host immune responses in a vaccination-challenge study using a glycoprotein G deletion mutant vaccine strain of infectious laryngotracheitis virus

Description

Gayathri Gopakumar and four co-authors read the gene activity of vaccinated chickens to show how a weakened virus vaccine shields the windpipe. Their study, published in 2024, uses a vaccine strain of infectious laryngotracheitis virus missing its glycoprotein G gene, known to be safe and effective. Blood and trachea samples were profiled before and after a virulent challenge.

Unvaccinated challenged birds showed a tracheal gene storm: fierce immune activation plus damage signals in cilia, nerves, cartilage, and cell junctions, matching their severe tissue pathology. Vaccinated challenged birds looked, at the gene level, almost identical to uninfected birds, with preserved lining and only mild immune cell presence. Blood profiles at seven days post-vaccination completed the picture. The authors present molecular proof that the deletion vaccine prevents disease, not just symptoms.

Catalog record

Source: https://europepmc.org/articles/PMC11802539