The mediating role of body surface area-adjusted basal metabolic rate: effects of low muscle mass and central obesity on cognitive impairment in Chinese patients with type 2 diabetes mellitus
Ya-Jie Zhai, Fang Li, Chen-Ying Lin, Fan Wu, Hui-Na Qiu, Jing-Bo Li, Jing-Na Lin · 2025
Read The mediating role of body surface area-adjusted basal metabolic rate: effects of low muscle mass and central obesity on cognitive impairment in Chinese patients with type 2 diabetes mellitus by Ya-Jie Zhai, Fang Li, Chen-Ying Lin, Fan Wu, Hui-Na Qiu, Jing-Bo Li, Jing-Na Lin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11802378.txt.
Description
Ya-Jie Zhai and six colleagues studied how body composition and resting energy use relate to thinking decline in Chinese diabetes patients, in a study published in 2024. The patients all had type 2 diabetes and were over forty-five. Central obesity and low muscle mass were the suspected risks.
The cross-sectional study enrolled 1,243 patients and tested thinking with a standard exam. Patients with impairment burned less energy at rest by every adjusted measure and carried less muscle and more waist fat. The top quarter of resting energy use came with roughly half the impairment risk of the bottom. Prediction improved when energy use and fat-free mass were combined. Mediation analysis suggested the size-adjusted energy measure carried about half the effect of waist and muscle on risk. The authors propose the measure as a screening aid for this group.
Catalog record
| CREATOR | Ya-Jie Zhai, Fang Li, Chen-Ying Lin, Fan Wu, Hui-Na Qiu, Jing-Bo Li, Jing-Na Lin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |