Electrical stimulation of the sciatic nerve restores inspiratory diaphragm function in mice after spinal cord injury
Ian Walling, Sarah Baumgartner, Mitesh Patel, Steven A. Crone · 2025
Read Electrical stimulation of the sciatic nerve restores inspiratory diaphragm function in mice after spinal cord injury by Ian Walling, Sarah Baumgartner, Mitesh Patel, Steven A. Crone (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11794311.txt.
Description
Ian Walling and co-authors showed that leg nerve stimulation can restore breathing drive after neck spinal injury in mice, published in 2024. High neck injuries cut the path from brainstem breath centers to the diaphragm. Limb nerve signals are known to raise breathing in healthy bodies. Whether they help after injury was unknown.
The team cut one side of the upper cord in anesthetized mice. They then zapped the sciatic nerve and recorded diaphragm bursts. At strong enough currents, either leg nerve revived breath bursts on the hurt side. Burst size and rate were tracked across thresholds. The trick might one day support breathing after human cord injury.
Catalog record
| CREATOR | Ian Walling, Sarah Baumgartner, Mitesh Patel, Steven A. Crone |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |