Effectiveness of antimicrobial agent combinations against carbapenem-producing Klebsiella pneumoniae with KPC variants in China
Congcong Liu, Yuchen Wu, Yanyan Zhang, Zelin Yan, Danxia Gu, Hongwei Zhou, Ning Dong, Chang Cai, Gongxiang Chen, Rong Zhang · 2025
Read Effectiveness of antimicrobial agent combinations against carbapenem-producing Klebsiella pneumoniae with KPC variants in China by Congcong Liu, Yuchen Wu, Yanyan Zhang, Zelin Yan, Danxia Gu, Hongwei Zhou, Ning Dong, Chang Cai, Gongxiang Chen, Rong Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11794265.txt.
Description
Congcong Liu and co-authors test drug combinations against carbapenem-resistant Klebsiella pneumoniae strains from China, in a 2025 paper. This bacterium resists last-line antibiotics and threatens hospitals worldwide. Single drugs often fail, so paired therapy is a common fallback. Which pairs work depends on the exact resistance enzyme each strain makes.
The team ran checkerboard assays on dozens of strains and many drug pairs. Strains carried different carbapenemases, including KPC variants. Some pairs showed synergy, where the drugs boost each other. Others added little or clashed. The results map pairs to enzyme types. Clinicians treating these infections gain lab-backed guidance. Stewardship teams can also curb useless combinations. More patient studies must confirm the lab findings.
Catalog record
| CREATOR | Congcong Liu, Yuchen Wu, Yanyan Zhang, Zelin Yan, Danxia Gu, Hongwei Zhou, Ning Dong, Chang Cai, Gongxiang Chen, Rong Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |