5,10-methylenetetrahydrofolate reductase C677T gene polymorphism as a risk factor for premature coronary artery disease in patients with type 2 diabetes mellitus
Nisreen O. Mohammed, Ibtisam A. Ali, Bahaelddin K. Elamin, Bakri Osman Saeed · 2025
Read 5,10-methylenetetrahydrofolate reductase C677T gene polymorphism as a risk factor for premature coronary artery disease in patients with type 2 diabetes mellitus by Nisreen O. Mohammed, Ibtisam A. Ali, Bahaelddin K. Elamin, Bakri Osman Saeed (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11794260.txt.
Description
Nisreen Mohammed and three co-authors test a gene variant as a risk factor for early heart disease in Sudanese patients with type 2 diabetes in this paper, published in 2024. The variant, called C677T, sits in a gene named MTHFR that helps process folate. It has been linked to high homocysteine, a blood factor tied to artery damage. The team enrolled 226 patients in Khartoum. Half had early coronary artery disease confirmed by imaging, and half had none.
Gene tests split the groups sharply. The risk form of the variant appeared in sixteen percent of the disease group and in none of the control group. Homocysteine itself linked strongly with disease. The authors conclude the variant and high homocysteine both mark risk for early heart disease in this population. They present the study as the first of its kind in Sudan.
Catalog record
| CREATOR | Nisreen O. Mohammed, Ibtisam A. Ali, Bahaelddin K. Elamin, Bakri Osman Saeed |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |