Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway
Ju Huang, Jing Li, Zhijun Geng, Lixia Yin, Minzhu Niu, Qingqing Li, Xinyue Liu, Xinke Cheng, Xiaofeng Zhang, Xue Song, Yueyue Wang, Lian Wang, Lugen Zuo, Jianguo Hu · 2025
Read Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway by Ju Huang, Jing Li, Zhijun Geng, Lixia Yin, Minzhu Niu, Qingqing Li, Xinyue Liu, Xinke Cheng, Xiaofeng Zhang, Xue Song, Yueyue Wang, Lian Wang, Lugen Zuo, Jianguo Hu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11788346.txt.
Description
Ju Huang and co-authors tested in 2025 whether a plant compound called cynaroside can calm severe gut inflammation. In Crohn's disease, too many intestinal lining cells die, which breaks the gut barrier and feeds colitis. The team used a chemical model of colitis in mice and a lab model of inflamed gut tissue. They tracked symptoms, tissue damage, and barrier strength.
Treated mice lost less weight and kept longer, healthier colons than untreated ones. Inflammation signals in the tissue fell. The compound protected the tight junctions that seal the gut lining and reduced the death of lining cells. Network analysis pointed to the PI3K/AKT pathway as the route of action. Organoid tests backed that mechanism. The authors propose cynaroside as a candidate for further Crohn's research. Human evidence, they note, does not yet exist.
Catalog record
| CREATOR | Ju Huang, Jing Li, Zhijun Geng, Lixia Yin, Minzhu Niu, Qingqing Li, Xinyue Liu, Xinke Cheng, Xiaofeng Zhang, Xue Song, Yueyue Wang, Lian Wang, Lugen Zuo, Jianguo Hu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |