SERINC5 counters retroviruses and non-retroviruses
Jinghua Yu, Chunyu Liu, Xinglong Qu, Xinglin Gao, Yue Liu · 2025
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Description
Jinghua Yu and four co-authors review SERINC5, a host protein that counters retroviruses and non-retroviruses alike. SERINC5 sits in the cell membrane and blocks a virus from fusing with the cell, which keeps the viral core out and cuts infectivity. Their review, shown as 2024 in the text, sums up the fight on two fronts: the retroviruses, where the protein was first found, and the wider virus world beyond them.
Three retroviruses have each evolved a countermeasure: viral proteins that send SERINC5 for degradation through the cell's waste system. Beyond blocking entry, the protein also modulates immunity, which slows replication of both virus kinds. The story makes SERINC5 a lead for drug research: protect it, mimic it, or block its viral foes, and a broad shield may rise, the authors hold.
Catalog record
| CREATOR | Jinghua Yu, Chunyu Liu, Xinglong Qu, Xinglin Gao, Yue Liu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |